6 Pre-Workout Ingredients You Can Take for a Better Pump

Usually getting a “pump” during your workout is considered a bodybuilding thing. Skin-stretching biceps and pulsating vascularity seem like they’re just for aesthetic purposes, for gymbros and gals who want to look swole before heading to the beach.

But it can actually serve an athletic purpose as well: if you’re increasing bloodflow to your muscles, research published in the American Journal of Physiology concludes,

The data suggest a link between the stimulation of protein synthesis after exercise and an acceleration in amino acid transport. The greater rate of transport after exercise may be due to the increase in blood flow (1)

In other words, the more blood flow you’re sending to an area the better your hypertrophy. (If you need convincing of the strength specific benefits of hypertrophy, we’ve got you covered.) Research from the European Journal of Applied Physiology suggests a pump may also help with post-activation potentiation, an advanced but super useful strength training protocol, and more blood flow to your muscles means they’re receiving more nutrients.(2)

So while we wouldn’t say it’s necessary for every athlete, it’s untrue to say that it’s a waste of time to train for a better pump.

A lot of getting a pump comes down to increasing your nitric oxide, a gas responsible for dilating blood vessels in response to muscle stress, so oxygen can be delivered through the blood with increased efficiency, according to a 2008 study in Antioxidants & Redox Signaling. (3)

And there are supplements that might help.


1. Citrulline malate

Perhaps the best known and best supported, this non-essential amino acid’s name comes from the Latin word for watermelon, which is a great source of the stuff. Citrulline malate is when it’s bound with malic acid and while a lot of people say arginine is better, they both compete for the same mechanism and citrulline absorbs better.

Research published in the International Journal of Cardiology and the European Journal of Applied Physiology found that a dose of 5 or so grams increases nitric oxide and blood flow. (4)(5) That’s important because a lot of pre-workouts only include one or two grams of the stuff.

[Citrulline is also one of the best preworkouts for power — check out the rest of the list.]


2. Trimethylglycine

Also called betaine, beets are a potent source of this compound and it’s part of the reason why beets are considered such a great food for athletes. Betaine is better known for its impact on power, but one study suggested supplementing with 6 grams per day for a week resulted in 185% more nitric oxide in the blood. Note that a more recent study in Nutrition didn’t manage to replicate this so it’s not ironclad, but it appears to have some effect.(6)

Remember that most supplements have no more than 2.5 grams of betaine since that’s what studies have found improves power, so it may be worth buying betaine on its own if you want to try this 6 grams per day schedule.

woman atlas stone arnold

3. Agmatine

So agmatine isn’t a precursor for nitric oxide, but what it does appear to do is relax blood vessels (vasorelaxation) thereby helping with blood flow, according to a 2007 study in the Proceedings of the National Academy of Sciences of the United States of America(7). It also seems to inhibit the breakdown of nitric oxide, though the precise interactions with it are super complicated.(8)

Agmatine sulfate appears to be the best form for supplements, just make sure your dose is at least 1.5 grams.

[Learn more about agmatine in our article on what’s changing in strength supplements.]


4. Curcumin

There’s not a ton of evidence here but some research published in Nutrition Journal saw a very significant increase in nitric oxide following a daily 80-miligram dose of curcumin for four weeks.(9) This is considered a low dose, but it brought about an increase of 40 percent in nitric oxide, along with lower plasma triglycerides.

More research is needed here, but there’s a ton of hard evidence that curcumin also lowers inflammation — it’s the active component in turmeric. So it’s not a bad idea to supplement anyway.

[Turmeric is one of 6 adaptogens that may help strength athletes.]

5. Carbohydrates

Usually those preworkout tablespoons don’t contain many carbs but there’s a great argument to be made for buying some glucose to take with them. Research suggests that the insulin bump will help to increase blood flow.(10)(11)(12)

“Insulin is a potent vasodilator,” says Dr. Mike T. Nelson, a physiologist, nutrition consultant and adjunct professor at the Carrick Institute. “As best as we can figure out, consuming some carbs before training should bump up insulin. Simple carbs are easier to digest and typically have more of an insulin release overall.”

dark chocolate

6. Epicatechin

This is an antioxidant that a lot of people think is the same thing as cocoa extract. Cocoa extract is a great source of this antioxidant but it’s also found in tea and apples in lower amounts.

Unlike a couple of the previous entries there’s a ton of evidence and little doubt that epicatechins improve nitric oxide production. As assessed by flow-mediated vasodilation, epicatechins reliably improve blood flow by about 2 percent as well as potentially helping insulin sensitivity.(13)(14)(15)(16)

If you’re taking cocoa bean polyphenols the standard dose is 500 to 1000 milligrams but of course, you can always eat dark chocolate: about 40 grams or 200 calories of the stuff would make taking pills unnecessary.


1. Moore DR et al. Neuromuscular adaptations in human muscle following low intensity resistance training with vascular occlusion. Eur J Appl Physiol. 2004 Aug;92(4-5):399-406.
2. Biolo G, et al. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am J Physiol. 1997 Jul;273(1 Pt 1):E122-9.
3. Chen K, et al. Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal. 2008 Jul;10(7):1185-98.
4. Sureda A, et al. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010 Sep;110(2):341-51.
5. Ochiai M, et al. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. Int J Cardiol. 2012 Mar 8;155(2):257-61.
6. Küskü-Kiraz Z, et al. Effects of betaine supplementation on nitric oxide metabolism, atherosclerotic parameters, and fatty liver in guinea pigs fed a high cholesterol plus methionine diet. Nutrition. 2018 Jan;45:41-48.
7. Joshi MS, et al. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9982-7.
8. Galea E, et al. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J. 1996 May 15;316 ( Pt 1):247-9.
9. DiSilvestro RA, et al. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79.
10. Karpe F, et al. Effects of insulin on adipose tissue blood flow in man. J Physiol. 2002 May 1;540(Pt 3):1087-93.
11. Raitakari M, et al. Effects of insulin on blood flow and volume in skeletal muscle of patients with IDDM: studies using [15O]H2O, [15O]CO, and positron emission tomography. Diabetes. 1997 Dec;46(12):2017-21.
12. Clark MG, et al. Blood flow and muscle metabolism: a focus on insulin action. Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E241-58.
13. Brossette T, et al. Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells. Eur J Nutr. 2011 Oct;50(7):595-9.
14. Moreno-Ulloa A, et al. Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4441-6.
15. Steffen Y, et al. (-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase. Biochem Biophys Res Commun. 2007 Aug 3;359(3):828-33.
16. Grassi D, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008 Sep;138(9):1671-6.


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Nick is a content producer and journalist with over seven years’ experience reporting on four continents. His first articles about health were on a cholera outbreak in rural Kenya while he was reporting for a French humanitarian organization. His next writing job was covering the nightlife scene in Shanghai. He’s written on a lot of things.After Shanghai, he went on to produce a radio documentary about bodybuilding in Australia before finishing his Master’s degrees in Journalism and International Relations and heading to New York City. Here, he’s been writing on health full time for more than five years for outlets like BarBend, Men's Health, VICE, and Popular Science.No fan of writing in the third person, Nick’s passion for health stems from an interest in self improvement: How do we reach our potential?Questions like these took him through a lot of different areas of health and fitness like gymnastics, vegetarianism, kettlebell training, fasting, CrossFit, Paleo, and so on, until he realized (or decided) that strength training fit best with the ideas of continuous, measurable self improvement.At BarBend his writing focuses a little more on nutrition and long-form content with a heaping dose of strength training. His underlying belief is in the middle path: you don’t have to count every calorie and complete every workout in order to benefit from a healthy lifestyle and a stronger body. Plus, big traps are cool.