The Best Joint Supplements for Knee Pain and Cartilage Support

Joint pain is a common issue among those who lift heavy, run long distances, are getting older, or have an abundance of inflammation in the body. If you’re a gymgoer, you may notice heavy squats or high-intensity interval training might be affecting your knee health and causing you pain. Joint pain can majorly affect your everyday tasks, as well as take you away from many of the activities you love to do. However, there are supplements that can help.

You may be aware of many of the ingredients that might help with joint pain, such as omega-3 fatty acids, CBD, or turmeric, but there are plenty of supplements on the market that take varied approaches to ease your joint pain. Some of the best joint supplements out there can help maintain cartilage (like collagen), while others may decrease pain in specific areas (such as a topical cream). Whether you suffer from conditions like rheumatoid arthritis, osteoporosis, or inflammation, we have a list of the best joint supplements on the market that may help ease your pain.

Best Joint Supplements:

• Best Joint Supplement Overall: Transparent Labs Joint Support
• Best All-Natural Joint Supplement: Legion Fortify Joint Support
• Best Liquid Joint Supplement: Onnit JOINT Oil
• Best Topical Joint Supplement: FOCL Relief Cream
• Best Joint Supplement with Chondroitin: Physio Flex Pro

Editor’s note: The content on BarBend is meant to be informative in nature, but it should not be taken as medical advice. The opinions and articles on this site are not intended for use as diagnosis, prevention, and/or treatment of health problems. It’s always a good idea to talk to your doctor before beginning a new fitness, nutritional, and/or supplement routine. None of these supplements are meant to treat or cure any disease. If you feel you may be deficient in a particular nutrient or nutrients, please seek out a medical professional.

Best Joint Supplement Overall

This pick contains five simple, yet effective, ingredients, high dosages, and a very fair price tag, making it our top pick for optimizing joint health.

Transparent Labs Joint Support

If Transparent Labs is known for anything, it’s high dosages, and their joint supplement is no exception. It contains 500mg of curcumin C3 complex, 110mg of calcium fructoborate, 75mg of boswellin super, 40mg of UCII standardized chicken collagen, and 10mg of bioperine.

Derived from turmeric, curcumin is a natural antioxidant, according to Johns Hopkins Medicine. And this ingredient can help lower inflammation, which is a common issue for those with sensitive joints.

You’ll also find 75mg of boswellia serrata (Boswellin Super), which is an ayurvedic medicine used for inflammation and has been utilized recently for arthritis, inflammation, and other conditions like colitis. (4) Another bonus, one serving of this supp is only two capsules, whereas others may require three pills (or more). Each serving will cost about $1.93 making this a slightly higher, but still reasonably priced joint supplement.

Who Should Buy Transparent Labs Joint Support

• Folks who want a simple ingredient list with a formula that’s solely joint-health-focused.
• Anyone who wants ingredients specifically geared toward fighting inflammation will like the boswellin super and curcumin in this formula.
• People who want a joint supplement that is reasonably priced as this one is around $1.93 per serving.

Who Shouldn’t Buy Transparent Labs Joint Support

• Those who want pain-killer ingredients in their joint supplement.
• Anyone who wants a more robust ingredient list. This has five potentially effective ingredients, but you may be looking for more than that.
• Folks who prefer an oil or topical joint supplement.

Transparent Labs Joint Support Supplement offers anti-inflammatory ingredients at a reasonable price point.

Best All-Natural Joint Supplement

If you’re looking to add a joint supplement to your stack and your main priority is having an all-natural ingredient list, Legion Fortify is created with no artificial or synthetic ingredients of any kind.

Legion Fortify Joint Support

Legion Fortify Joint Support is an all-natural joint supplement formulated with six effective ingredients, which may provide relief from joint pain and inflammation. It contains 600mg of agmatine sulfate, which one study suggests reduced neuropathic pain significantly, which is often a factor in rheumatoid arthritis. (9) It also contains 500mg of Meriva®, which is a bioavailable turmeric supplement. This joint supplement contains 90mg of grape seed oil, which is suggested to have anti-arthritic properties and be a natural way to mitigate arthritic pain. (10)

Legion also includes anti-inflammatory boswellia serrata extract in a 25mg dose, which may reduce inflammation, and has been used in ayurvedic medicine and more recently, to help treat arthritic pain. (4) The addition of 500mg of vitamin C here may be beneficial for increasing type I collagen synthesis, which is important for bone, skin, and connective tissue.

Lastly, you’ll find type II collagen, which is the main collagen that makes up cartilage. One study found that supplementing with type II collagen allowed the user pain-free strenuous exercise, which may have been painful without supplementation. (11) This joint supplement requires you to take three pills per serving, and a serving will cost you around $1.60, which is a touch pricier than many joint supps, but we think the price is justified thanks to the thorough ingredient list.

Who Should Buy Legion Fortify Joint Support

• Folks who want an all-natural supplement with no fillers, or artificial or synthetic ingredients.
• Those who want to reduce neuropathic pain will enjoy the 600mg of agmatine sulfate present here.
• People who want to benefit from type I and type II collagen, as this contains type II and the addition of vitamin C, which may help synthesize type I collagen. Collagen may help with pain-free movement, as well as supporting joints, bones, and skin.

Who Shouldn’t Buy Legion Fortify Joint Support

• Folks who aren’t great at taking pills may want to opt for an oil formula or one that requires fewer than three pills per serving.
• Those who want joint support as part of a multivitamin may want to check for a multi that provides joint support.
• Anyone who isn’t tied to an all-natural formula may find less expensive options on the market.

Legion Fortify features six beneficial ingredients that may help mitigate or combat joint pain in the user. The all-natural formula is a bonus for those who prefer to avoid artificial and synthetic ingredients in their supplements.

Best Liquid Joint Supplement

If swallowing pills isn’t in the cards for you, or you just want to make it easier by stacking your supplements, you may want to opt for a joint health supplement that you can put into water or add to your daily greens powder drink. Whatever your reasoning is, Onnit JOINT Oil is a solid choice to consider.

Onnit JOINT Oil

Onnit JOINT Oil is formulated with joint health superstars fish oil, turmeric extract, borage seed oil, and avocado oil. The inclusion of 1,600mg of fish oil may be effective and beneficial for fighting cartilage degradation and maintaining healthy cartilage in the body. (13) This also contains 1,100mg of borage seed oil, which contains high amounts of gamma linoleic acid (GLA). GLA is thought to reduce inflammation and help with arthritic symptoms. (14) The addition of 100mg of turmeric extract adds to the anti-inflammatory lineup in this formula. (5)

This is a great option for those who don’t like taking pills, but want to reap the benefits of a joint supplement. This supplement is sugar-, gluten-, and dairy-free, but it does have one gram of sugar alcohol per serving. It also contains soy and fish, so if you are allergic or have a sensitivity to either, it may be best to avoid this supplement. Onnit JOINT Oil comes in a Tangerine Dream flavor, requires two teaspoons per serving, and each serving costs around $0.95.

Who Should Buy Onnit JOINT Oil

• Those who want a joint supplement that doesn’t require them to swallow any pills. This supp is liquid.
• Anyone who enjoys stacking their supplements will appreciate that this can be mixed into your pre-workout or your BCAA supplement drink.
• Folks who want a diverse anti-inflammatory ingredient list will like the borage oil and turmeric present here.

Who Shouldn’t Buy Onnit JOINT Oil

• Those who don’t enjoy a tangerine flavor may want to look elsewhere.
• Anyone who has a fish or soy allergy should steer clear of this supplement.
• Folks who prefer pills will find many other suitable options on this list.

If you’re looking for a joint supplement that doesn’t require you to take any pills, Onnit JOINT Oil may be a stellar choice for you. It contains anti-inflammatory ingredients, as well as those specifically geared toward joint health. Plus, it comes in a delicious Tangerine Dream flavor.

Best Topical Joint Supplement

Some people prefer a joint supplement that they can use topically. If you’re someone who wants to use a cream on the affected area rather than swallowing pills every day, this pick has hemp, mint, arnica, and eucalyptus, which can all help relieve pain and discomfort in joints and muscles.

FOCL Relief Cream

FOCL Relief Cream is a cream that has two options for either 1,000mg or 2,000mg of CBD per 3.38oz bottle. One study on joint pain in animals found that CBD was effective for both inhibiting pain signaling and for combating inflammation, which may reduce the pain and symptoms associated with joint pain. (15) This formula also contains arnica montana, which one study found to have similar effects to ibuprofen for reducing osteoarthritis pain. (16)

It also contains botanicals that may be helpful for reducing pain, such as menthol, which has a cooling effect on the skin and may help alleviate some discomfort. Another botanical is camphor oil, which is suggested to be helpful for inflammation, pain, and treatment for arthritis. (17)

This CBD relief cream has a diverse range of ingredients that all have some potential benefits for pain relief, reducing inflammation, and specifically addressing joint pain or arthritis. A single bottle will cost you around $40.00 for the 1,000mg of CBD or around $60.00 for the 2,000mg of CBD — but if you opt to purchase a three-pack, you’ll save 20 percent on both the 1,000 and 2,000mg bottles.

Who Should Buy FOCL Relief Cream

• Anyone looking for a topical way to treat joint pain or arthritis will enjoy this cooling CBD cream that you apply directly to your skin.
• Folks who want the option between 1,000mg and 2,000mg of CBD per bottle.
• Those who enjoy benefitting from botanic ingredients will like seeing the menthol, eucalyptus, camphor oil, and wintergreen inclusions here.

Who Shouldn’t Buy FOCL Relief Cream

• Those who don’t want to pay a lot for their joint supplement. This is a great option for those who don’t want to ingest a joint supplement, but it’s a bit pricier than some of our other picks.
• Anyone who has an adverse feeling toward CBD. This topical contains either 1,000 or 2,000mg of CBD per bottle.
• Folks who prefer a joint supplement they can ingest will want to opt for a pill or oil supplement.

FOCL Relief Cream is an excellent alternative joint supplement to traditional oral supplements. It provides potential pain relief from arthritis, joint pain, and muscle pain, and delivers CBD and cooling botanics of menthol, plus potential pain relief from camphor oil to round it out.

Best Joint Supplement with Chondroitin

Chondroitin is present as one of the building blocks of human cartilage, and supplementing with it may benefit joint pain caused by osteoarthritis. This supplement has 100mg of chondroitin sulfate sodium per serving, making it a good choice for joint pain and osteoarthritis management.

Physio Flex Pro

Osteoarthritis is a degenerative disorder where loss of cartilage occurs or where the cartilage around the bone is remodeled. (21) It is a chronic condition that affects joints, which may be especially painful after long bouts of inactivity or from weight-bearing activities. Chondroitin has been shown to have moderate success in pain management and function, but its real use may be best suited to helping those who suffer from osteoarthritis of the knees. (22)

Glucosamine is similar to chondroitin, and is also found in cartilage in the body and may be helpful for mitigating joint pain — you get 500mg of glucosamine per serving here. This ingredient may prevent type II collagen degradation while maintaining collagen synthesis and may be beneficial for those with rheumatoid arthritis or osteoporosis. (1)(23)

Luckily, this supplement only has a two capsule serving size and costs about $2 per serving, which is a bit higher than some others on this list. These are veggie capsules, though, and the company offers a 60 day money-back guarantee.

Who Should Buy Physio Flex Pro

• Those who have degenerative cartilage and are still doing weight-bearing activities (like lifting weights) may benefit from the 100mg of chondroitin in this supplement.
• People who want to address joint pain or chronic joint conditions will like the 500mg of glucosamine.
• Those who don’t want to take many capsules per serving — this only requires two for a full dose.

Who Shouldn’t Buy Physio Flex Pro

• Those who want more active pain-relief ingredients, like ibuprofen.
• Folks who want to save money. This supplement isn’t too pricey but there are cheaper options.

Chondroitin may be a very beneficial supplement to take for those who have osteoarthritis. However, it’s best to consult your doctor in order to properly address this chronic condition. Before you try this supplement, double check that it’s safe for your body.

Benefits of Joint Supplements

There are many potentially effective ingredients that you’ll find within joint supplements. Each ingredient may have different properties that make it more effective for some individuals than others. Below we list out a few of the more common ingredients in joint supps and dig deeper into their potential benefits.

Turmeric

Turmeric is a spice and ayurvedic medicine that has been used for centuries for its potential medicinal properties. It is most commonly used for its potential anti-inflammatory and antioxidant properties, which may make turmeric a very helpful health aid for a host of ailments. (24) As joint pain generally goes hand in hand with inflammation, turmeric may be an effective remedy to help combat stiffness and pain in the joints.

Boswellia Extract

Boswellia extract is another ayurvedic ingredient that has been used for centuries as a health aid for inflammatory conditions. More recently, it’s been touted for its potential effectiveness in conditions like arthritis, colitis, and asthma. (4)

CBD

Although cannabis has been used for centuries as a potential medicine, the War on Drugs put a halt on research backing CBD (and THC) as potential medicinal aids. Preclinical research shows CBD to be potentially effective in treating skin disorders, like psoriasis, but to potentially help with inflammatory conditions. (25) It’s important to note that legally, CBD contains (at most) 0.3 percent THC (the psychoactive component of the cannabis plant), and isn’t meant to give you a “high” feeling.

Chondroitin

Chondroitin is found in abundance in human and animal cartilage, and it is specifically known for its potential to help with pain management for those who suffer from osteoarthritis of the knees. (22)

Glucosamine

Glucosamine is closely linked with chondroitin for its potential in mitigating osteoarthritis and rheumatoid arthritis pain. Glucosamine is also found in human cartilage, making it a natural choice for joint pain reduction. (23)

Omega-3 Fatty Acids

Omega-3 fatty acids are essential fats, as they are not naturally produced in the body. Because you need to supplement your omega-3s, you may turn to eating eggs for breakfast, or adding a krill oil or fish oil pill to your regimen. Omega-3s may be beneficial for people with inflammation, and therefore, may be of use in mitigating joint pain or conditions like osteoarthritis. (20)

Collagen

There are over 60 scientific studies assessing the benefits of collagen for joint pain and erosion, bone density loss, and skin aging, and most studies point to hydrolysate collagen as an effective way to potentially mitigate all three conditions. Many studies have also found that hydrolysate collagen may be effective in collagenic tissue regeneration via collagen synthesis. (7)

How Much Do Joint Supplements Cost?

Joint supplements vary distinctly in their makeup, as there are so many different ingredients that may be beneficial for joint pain and associated conditions (such as rheumatoid arthritis and osteoporosis). They may be as simple as a turmeric supplement that contains only turmeric and black pepper, or these supps could be more extensive and contain 10 or more anti-inflammatory ingredients. Because of the wide variety, joint supplement costs also vary.

Best Joint Supplement Overall	Transparent Labs Joint Support Supplement	$54.99Per serving: $1.83
Best All-Natural Joint Supplement	Legion Fortify Joint Support	$49.99Per serving: $1.67
Best Liquid Joint Supplement	Onnit JOINT Oil	$32.95Per serving: $0.54
Best Topical Joint Supplement	FOCL Relief Cream	$39.00Per serving: $1.30
Best Joint Supplement with Chondroitin	Physio Flex Pro	$34.95Per serving: $2.00

This list contains supplements that cost as little as about $0.50 per serving to as high as about $2.00 per serving. Joint supplements are fairly affordable, which makes them an easy addition to your line-up — especially if you’re experiencing a lot of joint pain, or want to get ahead of the curve and prevent the possibility of joint pain.

How We Chose the Best Joint Supplements

Because there are so many potential ways to mitigate joint pain and degradation, we picked a variety of supplements to fit different needs and cover a range of potential benefits. We thought about price, possible conditions that need to be treated, form, ingredients, and dosages when we made these picks. Check out our supplement testing methodology for more information.

Price

When we make picks for our list, we try to include a diverse range of prices to make sure there is a supplement to fit most budgets. These joint supplements range from around $0.50 to around $2.00 per serving. Each ingredient list and dosage amount will differ from supplement to supplement, creating a wide range of price points to choose from. The level of quality, all-natural ingredients, and sourcing also make a difference in cost.

For example, turmeric supplements are typically pretty simple and often just contain two ingredients — turmeric and black pepper. Many supplements like this cost only around $0.55 per serving, so the simple ingredient list is often reflected in the lower price point.

Conditions

Joint pain is a singular problem with many origins. Your joint pain could be from growing older, lifting very heavy weights, or conditions like rheumatoid arthritis or osteoarthritis. Because joint pain has a variety of origins, we wanted to find supplements that may be best suited to each.

If it’s inflammation that’s causing joint pain, it may be beneficial to use a turmeric supplement or a fish-oil supplement. Whereas, if you’re suffering from degradation of cartilage, it may be best to utilize a collagen supplement. Whatever your needs are surrounding supplementing for joint pain, we are confident there’s a reliable option for you on this list.

Form

The form in which you take your joint supplement could make or break. Some may prefer pills, while others might opt for oils or topicals. The pills on this list differ in the number you have to take per serving, as well as the type of capsule they come in (vegetarian or gelatin). We included an oil for those who have a hard time swallowing any number of pills, and we included a topical cream for those who prefer not to ingest their joint supplement entirely.

Ingredients and Dosage

Especially with joint supplements, the ingredient lists vary greatly from supplement to supplement. We chose a plethora of potentially effective ingredients (such as turmeric, chondroitin, collagen, botanics, and omega-3s) to provide options that may meet your needs to mitigate joint pain. These ingredients also greatly vary in their dosages and provide different mixes of ingredients.

Krill oil can be an example of a very simple ingredient list, as its only active ingredient is often just krill oil. On the other hand, an overall joint support supplement can contain around five or more active ingredients. All of the supplements we included on this list have a varying number of ingredients and dosages, which makes them unique in their makeup and suitable for specific needs — such as fighting inflammation or cartilage decay.

What to Consider Before Buying Joint Supplements

Since joint supplements vary so greatly based on content and makeup, there are several things you may want to consider before purchasing a joint supplement. Ingredients and dosage, form, and price are all factors we have detailed below.

Ingredients and Dosage

Ingredient lists and dosages are some of the most wide-ranged factors when it comes to buying supplements — and joint supplements are no exception. The ingredients that may be beneficial for joint pain are abundant, and therefore formulations vary significantly between products. This is why it is important to ask yourself what your main reason for wanting a joint supplement is. If it’s for mitigating inflammation, you may opt for a simple turmeric supplement. If you’re looking to prevent cartilage decay, you may want to utilize a supplement that also contains collagen.

Dosages are another important factor to consider when you’re picking a supplement. You want to make sure your supplement has effective dosages or provides a significant amount of your recommended daily intake. Each effective dose will be different depending on what the ingredient is, but overall, it’s recommended that you look at dosage amounts, and decide if they make sense for your individual needs before buying.

Form

The form your supplement comes in can be a major factor. If you hate swallowing pills, buying a supp that requires you to swallow five pills a day may not be your best bet. Whereas others may prefer the easy and mess-free formulation that pills offer. Some may want a topical formula that they can apply to the specific area of pain, rather than ingesting a pill or oil that may not be as targeted. Be sure to consider your lifestyle and preferences when picking a form for your joint supp — you’ll obviously want something that won’t be a hassle for you to stick to.

Price

Price is always an important factor to consider when adding a supplement to your regimen. There is no need to break the bank in order to find a reprieve from your joint pain. Joint supplements on this list are all fairly reasonable in price and range between about $0.50 to $2.00 per serving.

Although $2.00 is a drastic jump from $0.50, there are a lot of in-between prices that may fit your budget. And the more expensive supps are typically going to be for the more robust products. Consider what you’re willing to spend before you select the highest-dosed product or supplement with the longest list of ingredients — if your budget is $0.50 per serving, these options may be out of your price range.

Final Word

Whether you’re looking to preemptively protect your joints, suffer from conditions like arthritis, or feel the effect of heavy lifts or long runs, a joint supplement may be a great addition to your daily regimen. With an eclectic variety of ingredients on the market that may mitigate inflammation and joint pain, the only decision you’ll have to make is which one you want to utilize to optimize your joint health.

With inflammation and joint pain being significant issues for gymgoers, runners, and elderly folks, there is a plethora of options available to choose from. Ingredients like turmeric, omega-3 fatty acids, chondroitin, and CBD may have beneficial properties that allow you to participate in your favorite activities without a ton of pain in your joints. This list provides pills, oils, and topicals for you to choose from to allow you to select the supplement that makes the most sense for your goals and lifestyle.

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References