Glutamine is an amino acid — a building block for protein — that plays a role in several bodily functions. There are two types of glutamine. L-Glutamine, the type found in supplement form, plays a significant role in transporting nitrogen between organs. (1) Some evidence suggests glutamine helps maintain a healthy immune system and positively impacts the gut microbiome (read gut health). (2)(3)(4) There are also indications that glutamine aids post-workout recovery. (5)(6)
While the human body does produce glutamine, it is available in a variety of foods. Those who follow a well-balanced diet are likely getting an adequate amount of this amino acid daily. However, glutamine is most commonly available in meat and animal products, and so anyone following a vegan or vegetarian diet may consider a glutamine supplement to bolster their intake. With so many glutamine supplements available on the market, it’s important to know how to distinguish between options. Before deciding which of the following glutamine supplements is best for you, keep in mind that it’s wise to consult a medical professional before introducing additional glutamine to your diet.
- Best Glutamine Supplement: Transparent Labs RawSeries L-Glutamine
- Best BCAA Glutamine Supplement: Transparent Labs BCAA Glutamine
- Best N-Acetyl Glutamine: BulkSupplements N-Acetyl L-Glutamine
- Best Glutamine Powder Bag: BulkSupplements Glutamine Powder
- Best Glutamine Capsules: NOW Supplements L-Glutamine
Editor’s note: The content on BarBend is meant to be informative in nature, but it should not be taken as medical advice. The opinions and articles on this site are not intended to diagnose, prevent, and/or treat health problems. It’s always a good idea to talk to your doctor before beginning a new fitness, nutritional, and/or supplement routine.
Best Glutamine Supplement
Each single-scoop serving of this supplement provides 5,000mg of fermented L-Glutamine. Each 600-gram container provides 120 servings and includes no additional ingredients. You can also buy two or three bottles at once if you prefer to buy in bulk. The powder is unflavored, gluten-free, non-GMO, and contains no artificial sweeteners, flavorings or colorings. You can simply mix this powder into four to six ounces of water, and drink it with meals before exercise or directly following exercise.
Each container of this supplement provides 60 unflavored single-scoop servings, each with five grams of fermented L-Glutamine. There are no additional ingredients, it is hypoallergenic, vegan, GMO-free, and kosher.
Who Should Buy Transparent Labs RawSeries L-Glutamine
- Those who value supplements that are free of artificial ingredients.
- Anyone who needs their glutamine supplement to be gluten-free.
- Folks who want a very high dose of glutamine compared to many other top options on the market.
Who Shouldn’t Buy Transparent Labs RawSeries L-Glutamine
- People who would prefer taking a capsule in place of a powder.
- Those who prefer to consume powder supplements that have a flavor to them.
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Best BCAA Glutamine Supplement
This glutamine supplement provides five grams of L-Glutamine per single-scoop serving. Each serving also provides four grams of L-Leucine, two grams of L-Isoleucine, two grams of L-Valine, one gram of coconut water powder, and 1,535 milligrams of Vitamin C. There are six flavors available: tropical punch, green apple, sour grape, orange, strawberry lemonade, and blue raspberry.
The additional ingredients include citric acid, natural flavor, and stevia. A notable difference compared to many other competitive options on the market is Transparent Lab’s glutamine supplement does contain 10 calories per serving and two grams of carbohydrate.
This glutamine supplement is gluten-free, non-GMO, and free of artificial preservatives. Each container provides 30 servings that contain 5000 milligrams of L-Glutamine and 1,535 milligrams of Vitamin C.
Who Should Buy Transparent Labs BCAA Glutamine
- Anyone happy to have flavor options for their glutamine supplement.
- Folks who value the added Vitamin C.
- People happy to have supplements free are artificial flavorings.
Who Shouldn’t Buy Transparent Labs BCAA Glutamine
- Those who want a cheaper alternative, as this product is a bit pricey compared to others on the market.
- Folks who would rather have a supplement with more servings per container.
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Best N-Acetyl Glutamine
Free of any added ingredients, each serving provides 500-milligrams of N-Acetyl L-Glutamine (an acetylated analog of L-Glutamine). Like most of what BulksSupplements produces, this product is free of soy, dairy, yeast sugar, additives, and gluten. It is third-party tested for purity, manufactured to cGMP standards, and lab-verified.
This glutamine supplement provides 200 servings of 500 milligrams of N-Acetyl L-Glutamine. There are no other added ingredients and it is free of soy, gluten, dairy, yeast, and sugar.
Who Should Buy BulkSupplements N-Acetyl L-Glutamine
- Those looking specifically for N-Acetyl L-Glutamine.
- People who appreciate third-party testing for purity and cGMP standards.
- Folks looking for a higher dose supplement.
Who Shouldn’t Buy BulkSupplements N-Acetyl L-Glutamine
- Anyone who would rather have an L-Glutamine supplement.
- Those who prefer supplements in capsule form over powders.
Best Glutamine Powder Bag
Each bag of BulkSupplements glutamine powder contains 100 servings that provide one gram of L-glutamine. There are no additional ingredients aside from the L-Glutamine, and the powder is free of sugar, soy, dairy, yeast, gluten, and additives. Each bag is manufactured to cGMP standards and is third-party tested for purity. The resealable bag can help preserve freshness and take up less storage space in your supplement cabinet.
Made by a company that prides itself in simple supplements, this L-Glutamine Powder contains no additional ingredients, is non-GMO, and third-party tested. Each 3.5-ounce bag provides 100 servings of 1000 milligrams of glutamine.
Who Should Buy BulkSupplements Glutamine Powder
- Folks who prioritize supplements that don’t have any additional ingredients.
- People looking for a high-dose supplement — each serving provides one gram of l-glutamine.
- Those who value third-party testing for product purity.
- Anyone happy to have their supplements in a resealable bag.
Who Shouldn’t Buy BulkSupplements Glutamine Powder
- Anyone who doesn’t have a scoop to properly measure each serving (there’s no scoop included).
- Those who prefer a glutamine powder that is flavored.
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Best Glutamine Capsules
These glutamine capsules are compatible with vegan and vegetarian diets, are halal, non-GMO, and kosher. Besides providing 500 milligrams of L-Glutamine, ingredients include rice flour, gelatin, and magnesium stearate. The formula is free of sugar, salt, yeast, wheat, gluten, corn, soy, milk, egg, shellfish, and preservatives. The capsules are flavorless and measure about three-quarters of an inch long. NOW Supplements produces these capsules in a Good Manufacturing Practices (GMP) facility (GMP certified).
This supplement is on the affordable end of the market, is vegan-friendly, halal, kosher, and non-GMO. It is produced in a Good Manufacturing Practices facility.
Who Should Buy NOW Supplements L-Glutamine
- Anyone who follows a vegan or vegetarian diet or keeps kosher or halal.
- Those working with tighter budgets.
- People who value products that are GMP-certified.
Who Shouldn’t Buy NOW Supplements L-Glutamine
- Anyone who needs a higher dose of glutamine than 500 milligrams.
- Those who would prefer their supplements in powder form.
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How We Decided Our Picks
Below are the factors that had the biggest influence on our top glutamine supplement choices.
Ingredients and Purity
Take a look at the supplement’s label to ensure there are no extraneous or unwanted ingredients. Some manufacturers will include additives for texture or flavor. As with any supplement, it is best to know know what you’re putting into your body. Check each product for third-party testing for purity and consider them more strongly than options that don’t.
Capsule vs. Powder
For some folks, this may come down to a matter of convenience. While powders allow you to be more accurate about how much of a supplement you’re ingesting, it may be cumbersome to mix up a drink regularly. On the other hand, capsules are generally a bit more expensive on a per gram basis but may be more convenient for folks who are on the go or have a busier morning routine.
Since the serving sizes can vary from product to product, divide the total cost by the number of grams in each container to get a sense of the cost per gram.
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What To Consider Before Buying
Even though L-Glutamine is a naturally occurring amino acid, start slow if you’re introducing it to your diet via supplements for the first time. It may be wise to start with half-sized servings for a few days to let your body acclimate to the new supplement— check in with a medical professional before introducing L-Glutamine to your diet.
Hall JC, Heel K, McCauley R. Glutamine. The British journal of surgery. 1996;83(3):305-312.
Demling RH. Nutrition, anabolism, and the wound healing process: an overview. Eplasty. 2009;9:e9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642618/.
Calder PC, Yaqoob P. Glutamine and the immune system. Amino acids. 1999;17(3):227-241. https://www.ncbi.nlm.nih.gov/pubmed/10582122.
- Krishna Rao R. Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of Epithelial Biology and Pharmacology. 2012;5(1):47-54.
- Legault Z, Bagnall N, Kimmerly DS. The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise. International journal of sport nutrition and exercise metabolism. 2015;25(5):417-426.
- English N. Is a Glutamine Supplement Actually Worth Your Money? BarBend. https://barbend.com/glutamine-supplements/. Published March 22, 2017.